AGING CAUSES A REORGANIZATION OF CORTICAL AND SPINAL CONTROL OF POSTURE


Nicotinamide adenine dinucleotide phosphate oxidase 2 deletion attenuates polyhexamethylene guanidine-induced lung injury in mice

e5000 vape Inhalation of polyhexamethylene guanidine phosphate (PHMG) can cause pulmonary fibrosis.Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (Nox) are enzymes that produce reactive oxygen species, which may be involved in tissue damage in various lung diseases.To investigate whether the Nox2 isoform of Nox is involved in the prog

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Ionizable polymeric nanocarriers for the codelivery of bi-adjuvant and neoantigens in combination tumor immunotherapy

Ionizable lipid nanocarriers have made historical contribution to COVID-19 mRNA vaccines.Here, we report ionizable polymeric nanoparticles that co-deliver bi-adjuvant and neoantigen peptides for cancer immunotherapy in combination with immune checkpoint blockade (ICB).Current cancer ICB benefits only a small subset of patients, largely due to a lac

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